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    After weaning PND21 pups were weighed and all animals received DEHP free chow for the remainder of the study Approximately 1–2 male and 1–2 offspring per litter were followed until 5 months of age the total number of animals per treatment group is between 5

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    Phthalates are a family of synthetic chemicals that have been widely used in medical automotive and consumer product industries Zota et al 2014 Phthalate free polyvinyl chloride PVC is rigid but with the addition of phthalates it becomes soft and flexible so that it can be molded and used for a wide variety of products such as personal care products baby toys food wrappings medical

  • Environmentally relevant exposure to diethylhexyl

    Author summary Faithful chromosome segregation during meiosis the specialized cell division program that produces haploid gametes i e eggs and sperm from a diploid organism is key for successful sexual reproduction Diethylhexyl phthalate DEHP a commonly used plasticizer found in personal care and products has emerged as an endocrine disruptor that exerts

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    Effects of DEHP on juvenile pairs social behaviors tests in F1 mice Mean ± SEM proportion of time spent A sitting side by side B sniffing partner C sitting alone and D exploring the cage

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  • Increased Serum Phthalates MEHP DEHP and Bisphenol A

    The aim of this study was to investigate the relationship between autism spectrum disorders development and exposure to mono 2 ethylhexyl phthalate MEHP di 2 ethylhexyl phthalate DEHP and bisphenol A BPA 1 of the endocrine disruptors among phthalates

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  • DEHP bis 2 ethylhexyl phthalate alters gene expression

    Diethylhexylphthalate DEHP is a widely distributed phthalate to which humans are exposed to due to its variety of commercial and manufacturing uses As a plasticiser it is found in a wide number of products and metabolites of DEHP have been detected in urine samples from a high percentage ofthe peoplescreened for phthalates We utilised DNA microarray analysis to evaluate DEHP for gene

  • Relationship between urinary concentrations of di 2

    Objectives We investigated the relationship between urinary metabolites of di 2 ethylhexyl phthalate DEHP and reproductive hormones in workers of polyvinyl chloride PVC production plants After exposure most of the DEHP is rapidly metabolised to mono 2 ethylhexyl phthalate MEHP mono 2 ethyl 5 hydroxyhexyl phthalate MEHHP and mono 2 ethyl 5 oxohexyl phthalate MEOHP which

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    Diethylhexylphthalate DEHP is a phthalate a chemical substance that is frequently used to soften PVC Polyvinyl Chloride medical devices such as blood bags tubing catheters and disposable gloves to make materials more pliable and comfortable to use The increasing knowledge of the effects of phthalate exposure which can be teratogenic carcinogenic or induce reproductive toxicity has

  • A Review of Possible Toxicity of DI 2 Ethylhexylphthalate

    Singh AR Lawrence WH Autian J Mutagenic and antifertility sensitivities of mice to di 2 ethylhexylphthalate DEHP and dimethoxyethyl phthalate DMEP Toxicol Appl Pharmacol 1974

  • In vitro effects of selected endocrine disruptors DEHP

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